[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

Base Information

Chemical Name:[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid
CAS No.:1334524-25-2
Molecular Formula:C₂₂H₃₆O₄S₂Si
Molecular Weight:456.743
Hs Code.:

Synonyms:[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

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Chemical Property of [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

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Technology Process of [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

There total 3 articles about [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1334524-24-1
triisopropylsilyl 4-(pyridine-2-yldisulfanyl)pentanoate

: 39161-85-8
alpha-mercaptophenylacetic acid

: 2637-34-5,73018-10-7
2-Sulfanylpyridine

: 1334524-25-2
[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

Guidance literature:: In tetrahydrofuran; at -10 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.039

Reference yield: 68.0%

: 1334524-24-1
triisopropylsilyl 4-(pyridine-2-yldisulfanyl)pentanoate

: 39161-85-8
alpha-mercaptophenylacetic acid

: 1334524-25-2
[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

Guidance literature:: In tetrahydrofuran; at -10 - 25 ℃;
DOI:10.1021/jm500631u

Reference yield:

: BrH*C₆H₁₂N₂O₂S

: 1334524-25-2
[2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 24 h / 75 °C / pH 10

2: ethanol / 16 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: tetrahydrofuran / 1.5 h / -10 - 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.05.039