(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal

Base Information

• Chemical Name: (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal
• CAS No.: 118949-48-7
• Molecular Formula: C₅₁H₁₀₄O₆Si₄
• Molecular Weight: 925.725
• Mol file: 118949-48-7.mol

Synonyms:(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal

Chemical Property of (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal

There total 3 articles about (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide (116386-70-0) → (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal (118949-48-7)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -30 ℃;

DOI:10.1021/ja00185a071

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal (118949-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

2: 98 percent / DIBAl / tetrahydrofuran / -30 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00185a071

Reference yield:

(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-hydroxy-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide (118977-90-5) → (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal (118949-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

2: 98 percent / DIBAl / tetrahydrofuran / -30 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00185a071

upstream raw materials:

(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide

t-butyldimethylsiyl triflate

(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-hydroxy-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide

Downstream raw materials:

C₆₉H₁₃₈O₈S₂Si₄

C₈₀H₁₅₅NO₁₁S₂Si₄

C₇₅H₁₅₂O₈S₂Si₅