5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

Base Information

Chemical Name:5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide
CAS No.:146516-03-2
Molecular Formula:C₁₉H₁₇N₅O₂
Molecular Weight:347.376
Hs Code.:

Synonyms:5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

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Chemical Property of 5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

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Technology Process of 5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

There total 3 articles about 5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 146516-09-8
5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

: 146516-03-2
5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Heating;
DOI:10.1021/jm00056a008

Reference yield:

: 1027222-09-8
Phosphoric acid 4-benzyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-yl ester diethyl ester

: 146516-03-2
5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, DMF, -78 deg C, 2 h

2: 90 percent / hydrazine hydrate / ethanol / 2 h / Heating

With hydrazine hydrate; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jm00056a008

Reference yield:

: 1843-49-8
4-benzyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 146516-03-2
5-Benzyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, from -20 to -10 deg C, 30 min

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, DMF, -78 deg C, 2 h

3: 90 percent / hydrazine hydrate / ethanol / 2 h / Heating

With sodium hydride; hydrazine hydrate; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jm00056a008