2-Methylamino-1-phenylpropan-2-ol hydrochloride

Base Information

• Chemical Name: 2-Methylamino-1-phenylpropan-2-ol hydrochloride
• CAS No.: 134-71-4
• Deprecated CAS: 77274-98-7
• Molecular Formula: C10H15 N O . Cl H
• Molecular Weight: 201.696
• Hs Code.: 29394100
• European Community (EC) Number: 205-153-9,246-090-7
• UNII: 43SK4LAO7D
• DSSTox Substance ID: DTXSID00889337,DTXSID40947041
• Wikidata: Q27258670
• NCI Thesaurus Code: C81365
• ChEMBL ID: CHEMBL2104837
• Mol file: 134-71-4.mol

Synonyms:24221-86-1;134-71-4;2-Methylamino-1-phenylpropan-2-ol hydrochloride;D-Ephedrine hydrochloride;(+)-Ephedrine, hydrochloride;(+)-EPHEDRINE HYDROCHLORIDE;EINECS 246-090-7;(1S,2R)-(+)-Ephedrine hydrochloride;43SK4LAO7D;(1S,2R)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride;Racephedrine HCl;Ephedrine, hydrochloride, (+)-;Racephedrine hydrochloride [USAN];(S-(R*,S*))-alpha-(1-(Methylamino)ethyl)benzenemethanol, hydrochloride;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,S*))-;( inverted exclamation markA)-Ephedrine (hydrochloride);Racephedrine Hydrochloride (USAN);Ephedrine, hydrochloride, ()-;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-;UNII-43SK4LAO7D;Ephedrine dl- hydrochloride;C10H15NO.ClH;Ephedrine dl-form hydrochloride;Ephedrine hydrochloride, racemic;Ephedrine, hydrochloride, (+-)-;(+/-)-2-Ephedrinium Hydrochloride;EC 205-153-9;Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, hydrochloride, [S-(R*,S*)]-;Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, hydrochloride,[S-(R*,S*)]-;()-Eperisone hydrochloride;dl-alpha(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;1S,2R(+)-Ephedrine HCl;Ephedrine hydrochloride, 99%;SCHEMBL321655;(R*,S*)-(+-)-alpha-(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;(R*,S*)-(1)-alpha-(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;Benzenemethanol, ?-[1-(methylamino)ethyl]-, hydrochloride, [R-(R,S)]-;CHEMBL2104837;DTXSID00889337;DTXSID40947041;Bencenometanol, Alfa-[(1S)-1-(metilamino) etil]-, clorhidrato (1:1), (Alfa R)-;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-rel-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (theta,S)-(+/-)-;HY-B0980;AKOS027321135;CS-4470;NSC 757308;LS-63971;RACEPHEDRINE HYDROCHLORIDE [MART.];RACEPHEDRINE HYDROCHLORIDE [WHO-DD];EPHEDRINE DL-FORM HYDROCHLORIDE [MI];(1S,2R)-(+)-Ephedrine hydrochloride, 99%;D08982;A806827;Ephedrine hydrochloride (racemic) - Drug Precursor;(+)-Ephedrine hydrochloride, purum, >=99.0% (AT);EPHEDRINE HYDROCHLORIDE, RACEMIC [EP MONOGRAPH];Q27258670;(1S,2R)-2-(methylamino)-1-phenyl-1-propanol hydrochloride;(1S,2R)-2-(methylamino)-1-phenyl-propan-1-ol hydrochloride;(1S,2R)-(+)-Ephedrine Hydrochloride 1.0 mg/ml in Methanol (as free base);Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-rel-;Ephedrine hydrochloride (racemic), European Pharmacopoeia (EP) Reference Standard;(1S,2R)-(+)-Ephedrine hydrochloride, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material

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Chemical Property of 2-Methylamino-1-phenylpropan-2-ol hydrochloride

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.000881mmHg at 25°C
• Melting Point: 216-220 °C(lit.)
• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 85.6 °C
• PSA: 32.26000
• LogP: 2.52080
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: soluble5%, clear, colorless
• Water Solubility.: 250g/L at 20℃
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 121

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36-25-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)NC.Cl
• Isomeric SMILES: C[C@H]([C@H](C1=CC=CC=C1)O)NC.Cl
• Description: Ephedrine is an alkaloid, which is from dry grass stems of ephedra plants such as ephedra, zhong ephedra, or ephedra. Ephedra is an herb recorded in “Chinese Pharmacopoeia,” which can be used for sweating and cold, adjustment of lung function, asthma, and swelling. Ephedrine can treat cold, chest tightness, bronchial asthma, and so on. Ephedra was used as a drug in China for more than 2000 years, which was recorded in history books of materia medica. Ephedra is also known as Longsa recorded in the book Shen Nong’s Herbal Classic of Materia Medica, Bixiang recorded in the book Another record by famous record, and Gougu recorded in the book Guang Ya. Ephedra was firstly recorded in the book Shen Nong’s Classic of Materia Medica.
• Physical properties: Appearance: a white needle-like crystal or crystalline powder, odorless, and tastes bitter. Solubility: soluble in water and can be dissolved in ethanol but insoluble in chloroform or ether. Melting point: 217–220 °C.
• Uses: bronchodilator, cardiac stimulant α- and β-Adrenergic agonist. Bronchodilator.
• Clinical Use: In clinical practice, ephedrine hydrochloride was used for the treatment of bronchial asthma, hypotension, central excitation , and toxicity by morphine and barbiturate. Ephedrine hydrochloride was also used to eliminate nasal mucosal congestion. Drug tolerance can occur quickly when ephedrine hydrochloride was used often in a short time. Ephedrine hydrochloride can also be used for hypotension and chronic hypotension caused by subarachnoid anesthesia or epidural anesthesia .