ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
CAS No.:1269118-94-6
Molecular Formula:C₂₂H₂₆ClN₃O₄
Molecular Weight:431.919
Hs Code.:

Synonyms:ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Chemical Property of ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Technology Process of ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

There total 8 articles about ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1269118-89-9
ethyl 2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 1269118-94-6
ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: ethyl 2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate; With lithium hydroxide monohydrate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 70 ℃; for 0.166667h;

1-bromomethyl-3-chlorobenzene; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 70 ℃; for 5h;

Reference yield:

: 3709-98-6
2-ethylpyrimidine-4,6-diol

: 1269118-94-6
ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 17 h / 10 °C / Reflux

2.1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol / 0.5 h / 10 - 35 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 35 °C / Cooling with ice

4.1: triethylamine / 1 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 19.5 h / 10 - 35 °C

6.1: sodium ethanolate / ethanol / 0.25 h / 10 - 35 °C

6.2: 0.5 h / 0 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4.5 h / 35 °C / Cooling with ice

8.1: sodium acetate; acetic acid / 1 h / Reflux

9.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.17 h / 70 °C

9.2: 5 h / 70 °C

With sodium chlorite; oxalyl dichloride; lithium hydroxide monohydrate; aminosulfonic acid; sodium ethanolate; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1269118-44-6
C₇H₆Cl₂N₂O₂

: 1269118-94-6
ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 35 °C / Cooling with ice

2.1: triethylamine / 1 h / 35 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 19.5 h / 10 - 35 °C

4.1: sodium ethanolate / ethanol / 0.25 h / 10 - 35 °C

4.2: 0.5 h / 0 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4.5 h / 35 °C / Cooling with ice

6.1: sodium acetate; acetic acid / 1 h / Reflux

7.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.17 h / 70 °C

7.2: 5 h / 70 °C

With oxalyl dichloride; lithium hydroxide monohydrate; sodium ethanolate; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;