{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

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Chemical Name:{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone
CAS No.:1418296-75-9
Molecular Formula:C₂₅H₂₃F₄N₃O₂
Molecular Weight:473.47
Hs Code.:

Synonyms:{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

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Chemical Property of {3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

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Technology Process of {3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

There total 9 articles about {3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1418297-45-6
3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418297-49-0
3-(pyrrolidin-1-ylcarbonyl)benzyl methanesulphonate

: 1418296-75-9
{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: With potassium tert-butylate; In 1,4-dioxane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-75-9
{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

6.1: potassium tert-butylate / 1,4-dioxane / 0.5 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-75-9
{3-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

5.1: potassium tert-butylate / 1,4-dioxane / 0.5 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;