[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

Base Information

Chemical Name:[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide
CAS No.:1404529-99-2
Molecular Formula:C₃₁H₃₂ClN₇O₃
Molecular Weight:586.093
Hs Code.:

Synonyms:[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

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Chemical Property of [4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

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Technology Process of [4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

There total 23 articles about [4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 109-01-3
1-methyl-piperazine

: 1404533-23-8
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid

: 1404529-99-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

Guidance literature:: 1-methyl-piperazine; {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 20 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; acetone;
DOI:10.1021/jm500588w

Reference yield:

: 1404531-75-4
{3-[2-bromo-4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid methyl ester

: 1404529-99-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: sodium hydroxide; methanol / 1,4-dioxane / 20 °C

3: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm500588w

Reference yield:

: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid methyl ester

: 1404529-99-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)-2-cyano-phenyl]-5-chloro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; methanol / 1,4-dioxane / 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With methanol; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm500588w