ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

Base Information

Chemical Name:ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate
CAS No.:1152431-43-0
Molecular Formula:C₂₈H₃₆N₄O₃
Molecular Weight:476.619
Hs Code.:

Synonyms:ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

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Chemical Property of ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

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Technology Process of ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

There total 4 articles about ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 214707-91-2
1-isopropyl-1H-indazole-3-carboxylic acid (piperidin-4-ylmethyl)-amide

: 74003-31-9
4-bromoethylbenzoic acid ethyl ester

: 1152431-43-0
ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: With triethylamine; In butanone; for 48h; Reflux;
DOI:10.1021/jm300573d

Reference yield:

: 214707-75-2
1-isopropyl-1H-indazole-3-carbonyl chloride

: 1152431-43-0
ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 12 h / 20 °C

2: hydrogenchloride / ethanol

3: hydrogen; palladium 10% on activated carbon / ethanol; acetic acid / 24 h / 20 °C / 1810.07 Torr

4: triethylamine / butanone / 48 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; acetic acid; toluene; butanone;
DOI:10.1021/jm300573d

Reference yield:

: 214707-76-3
1-isopropyl-N-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-indazole-3-carboxamide

: 1152431-43-0
ethyl 4-[2-[4-[[[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol

2: hydrogen; palladium 10% on activated carbon / ethanol; acetic acid / 24 h / 20 °C / 1810.07 Torr

3: triethylamine / butanone / 48 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; acetic acid; butanone;
DOI:10.1021/jm300573d