<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

Base Information

Chemical Name:<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester
CAS No.:126166-89-0
Molecular Formula:C₃₅H₃₉N₃O₉
Molecular Weight:645.709
Hs Code.:

Synonyms:<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

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Chemical Property of <(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

Chemical Property:

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Technology Process of <(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

There total 4 articles about <(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-[(R)-2-((S)-3-Benzyloxycarbonyl-3-benzyloxycarbonylamino-propoxycarbonylamino)-3-phenylmethanesulfinyl-propionylamino]-3-methyl-butyric acid benzyl ester

: 126166-89-0
<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

Guidance literature:: In xylene; at 150 ℃; for 4h; Yield given;
DOI:10.1016/S0040-4020(01)80113-7

Reference yield:

: 58578-44-2
benzyl L-2-<(carbobenzxyloxy)amino>-4-hydroxybutyrate

: 126166-89-0
<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / CH₂Cl₂ / 20 h / Ambient temperature

2: 80 percent / dimethylaminopyridine / acetonitrile / 45 deg C, 24 h, then RT, 36 h

3: mCPBA / CH₂Cl₂ / 0.75 h / Ambient temperature

4: xylene / 4 h / 150 °C

With dmap; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; xylene;
DOI:10.1016/S0040-4020(01)80113-7

Reference yield:

: 126166-87-8
N-benzyloxycarbonyl-O-carbonylimidazole-(2S)-homoserine benzyl ester

: 126166-89-0
<(5S)-5-benzyloxycarbonylamino-5-benzyloxycarbonyl>-2-oxapentanoyldidehydroalaninyl-(2R)-valine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / dimethylaminopyridine / acetonitrile / 45 deg C, 24 h, then RT, 36 h

2: mCPBA / CH₂Cl₂ / 0.75 h / Ambient temperature

3: xylene / 4 h / 150 °C

With dmap; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; xylene;
DOI:10.1016/S0040-4020(01)80113-7