dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

Base Information

Chemical Name:dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate
CAS No.:131727-04-3
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

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Chemical Property of dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

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Technology Process of dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

There total 1 articles about dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 9b-Chloro-2-((S)-1-phenyl-ethyl)-2,3,4,9b-tetrahydro-1H-pyrido[4,3-b]indole

: 77628-37-6
thallium dimethyl malonate

: 131727-04-3
dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

Guidance literature:: In tetrahydrofuran; Yield given; 1.) room temperature, 3 h, 2.) reflux, 20 h;
DOI:10.1021/jo00002a008

Reference yield: 80.0%

: 131727-04-3
dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

: 131703-74-7,131703-75-8
methyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5ξ,6-hexahydroazepino<4,5-b>indole-5-carboxylate

Guidance literature:: With triethylamine hydrochloride; lithium chloride; In N,N-dimethyl acetamide; at 120 ℃; for 1h;
DOI:10.1021/jo00002a008

Reference yield:

: 131727-04-3
dimethyl 3-<(S)-α-methylbenzyl>-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5,5-dicarboxylate

: 131703-83-8,131829-89-5
methyl 3-<(S)-α-methylbenzyl>-2,3,3a,4,5,7-hexahydro-4-<(2R)-2-ethyl-2,3-dihydroxypropyl>-1H-pyrrolo<2,3-d>carbazole-6-carboxylate acetonide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / LiCl, Et₃N*HCl / N,N-dimethyl-acetamide / 1 h / 120 °C

2: 60 percent / toluene / 24 h / Heating

With triethylamine hydrochloride; lithium chloride; In N,N-dimethyl acetamide; toluene;
DOI:10.1021/jo00002a008