5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

Base Information

Chemical Name:5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one
CAS No.:1448195-21-8
Molecular Formula:C₁₈H₁₉N₃O₄
Molecular Weight:341.367
Hs Code.:

Synonyms:5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

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Chemical Property of 5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

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Technology Process of 5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

There total 3 articles about 5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 60923-13-9
2-(azidomethyl)-5-hydroxy-4H-pyran-4-one

: 1448195-23-0
1,2,3-trimethyl-5-(prop-2-yn-1-yloxy)benzene

: 1448195-21-8
5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201300889

Reference yield:

: 527-54-8
3,4,5-trimethylphenol

: 1448195-21-8
5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / 65 °C / Reflux; Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In tetrahydrofuran; water; acetone;
DOI:10.1002/chem.201300889

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1448195-21-8
5-hydroxy-2-{(4-[(3,4,5-trimethylphenoxy)methyl]-1H-1,2,3-triazol-1-yl)-methyl}-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 4 h / 0 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere; Darkness

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With thionyl chloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201300889