(S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide

Base Information

• Chemical Name: (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide
• CAS No.: 159142-09-3
• Molecular Formula: C₃₈H₄₆N₄O₅S
• Molecular Weight: 670.873

Synonyms:(S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide

Chemical Property of (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide

There total 3 articles about (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

[2R-(2R*,3S,)]-N-t-Butyl-2-(3-amino-2-hydroxy-4-phenylbutyl) benzamide (157309-35-8) + (S)-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinylthio)propionic acid (159142-07-1) → (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide (159142-09-3)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; a) 0 deg C, 2 h, b) RT, overnight;

DOI:10.1021/jm950576c

Reference yield:

N-(tert-butyloxycarbonyl)-D-serine β-lactone (98541-64-1,132340-68-2,126330-77-6) → (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide (159142-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 10 min, 2.) THF, RT, 2 h

2: 51 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

With sodium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm950576c

Reference yield:

Quinoline-2-thiol (2637-37-8) → (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide (159142-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 10 min, 2.) THF, RT, 2 h

2: 51 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

With sodium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm950576c

upstream raw materials:

[2R-(2R*,3S,)]-N-t-Butyl-2-(3-amino-2-hydroxy-4-phenylbutyl) benzamide

(S)-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinylthio)propionic acid

N-(tert-butyloxycarbonyl)-D-serine β-lactone

Quinoline-2-thiol

Downstream raw materials:

(S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(methylsulfonyl)amino>-3-(2-quinolinylthio)propanamide

(S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-(acetoxyamino)-3-(2-quinolinylthio)propanamide

2-{(2R,3S)-3-[(S)-2-Amino-3-(quinolin-2-ylsulfanyl)-propionylamino]-2-hydroxy-4-phenyl-butyl}-N-tert-butyl-benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159142-09-3 (S)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(tert-butoxycarbonyl)amino>-3-(2-quinolinyl)propanamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send