4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

Base Information

Chemical Name:4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester
CAS No.:637780-41-7
Molecular Formula:C₁₄H₁₅N₅O₅
Molecular Weight:333.304
Hs Code.:

Synonyms:4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

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Chemical Property of 4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

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Technology Process of 4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

There total 6 articles about 4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100643-27-4,143504-99-8
2,6-diamino-3H-pyrimidin-4-one

: 145344-28-1,115665-98-0
methyl (E)-4-(2’-nitrovinyl)benzoate

: 637780-41-7
4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

Guidance literature:: In water; ethyl acetate; at 50 ℃; for 24h;
DOI:10.1021/jo030248h

Reference yield:

: 90923-10-7
4-(1-hydroxy-2-nitroethyl)benzoic acid methyl ester

: 637780-41-7
4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / CH₃SO₂Cl; Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 84 percent / H₂O; ethyl acetate / 24 h / 50 °C

With methanesulfonyl chloride; triethylamine; In dichloromethane; water; ethyl acetate; 2: Michael addition;
DOI:10.1021/jo030248h

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 637780-41-7
4-[1-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-nitroethyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. NaOH / ethanol / 48 h / 38 °C

2: 85 percent / CH₃SO₂Cl; Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 84 percent / H₂O; ethyl acetate / 24 h / 50 °C

With sodium hydroxide; methanesulfonyl chloride; triethylamine; In ethanol; dichloromethane; water; ethyl acetate; 1: Henry reaction / 3: Michael addition;
DOI:10.1021/jo030248h