methyl <2-2H>mandelate

Base Information

• Chemical Name: methyl <2-2H>mandelate
• CAS No.: 14919-25-6
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 167.169
• Mol file: 14919-25-6.mol

Synonyms:methyl <2-2H>mandelate

Chemical Property of methyl <2-2H>mandelate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl <2-2H>mandelate

There total 5 articles about methyl <2-2H>mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) → methyl <2-2H>mandelate (14919-25-6)

Guidance literature:

With water-d2; sodium acetate; bis-diphenylphosphinomethane; cobalt(II) iodide; zinc; In acetonitrile; at 80 ℃; for 5h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201900636

Reference yield:

methyl 2-oxo-2-phenylacetate (15206-55-0) → (RS)-methyl mandelate (4358-87-6) + methyl <2-2H>mandelate (14919-25-6)

Guidance literature:

With methylmagnesium bromide; Br^(1-)*C₈H₆⁽²⁾HOS^(1-)*Mg⁽²⁺⁾; 1-Benzyl-3-(pyrrolidine-1-carbonyl)-pyridinium; bromide; In tetrahydrofuran; acetonitrile; at 20 ℃; for 4h; Overall yield = 63 percent; Overall yield = 6.4 mg; Inert atmosphere;

DOI:10.1039/d0cc05185c

Reference yield:

methyl 2-oxo-2-phenylacetate (15206-55-0) → methyl <2-2H>mandelate (14919-25-6) + dimethyl 2,3-dihydroxy-2,3-diphenylbutanedioate (81390-14-9) + dimethyl 2,3-dihydroxy-2,3-diphenylbutanedioate (74956-42-6,81390-14-9,81390-15-0)

Guidance literature:

With pyridine; titanium(III) chloride; water-d2; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h; Yields of byproduct given;

DOI:10.1016/0040-4020(95)00872-6

upstream raw materials:

methyl 2-oxo-2-phenylacetate

Benzoylformic acid

Downstream raw materials:

α-deutero mandelic acid