4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid

Base Information

• Chemical Name: 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid
• CAS No.: 1620775-42-9
• Molecular Formula: C₂₁H₁₇ClF₃N₅O₃
• Molecular Weight: 481.83

Synonyms:4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid

Chemical Property of 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid

Chemical Property:

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Technology Process of 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid

There total 4 articles about 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoate (1620775-46-3) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoic acid (1620775-42-9)

Guidance literature:

methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoate; With potassium carbonate; In water; acetone; at 80 ℃; for 16h; Sealed tube;

With hydrogenchloride; In water; pH=2;

Reference yield:

C5(2)H2Cl2F3N3O (1620775-44-1) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoic acid (1620775-42-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 70 °C

3.1: potassium carbonate / acetone; water / 16 h / 80 °C / Sealed tube

3.2: pH 2

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetone;

Reference yield:

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoate (1620775-45-2) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoic acid (1620775-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 70 °C

2.1: potassium carbonate / acetone; water / 16 h / 80 °C / Sealed tube

2.2: pH 2

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetone;

upstream raw materials:

C₅⁽²⁾H₂Cl₂F₃N₃O

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoate

methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoate

4-methoxycarbonyl aniline

Downstream raw materials:

4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride

2-(4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzamido)-N,N,N-trimethylethanaminium

C₂₇H₂₈⁽²⁾H₂ClF₃N₁₀O₃

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