(+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate

Base Information

• Chemical Name: (+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate
• CAS No.: 1402235-57-7
• Molecular Formula: C₄₃H₆₇N₃O₆S
• Molecular Weight: 754.087
• Mol file: 1402235-57-7.mol

Synonyms:(+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate

Chemical Property of (+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate

There total 1 articles about (+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]-hept-2-en-2-yl}methanol (256934-39-1) + N-(+)-biotinyl-6-aminocaproic acid (72040-64-3) → (+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methyl 6-(biotinylamino)hexanoate (1402235-57-7)

Guidance literature:

N-(+)-biotinyl-6-aminocaproic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 77 ℃; for 0.833333h; Molecular sieve; Inert atmosphere;

With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Molecular sieve; Inert atmosphere;

(+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]-hept-2-en-2-yl}methanol; With dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 - 60 ℃; for 28h; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.201200467

upstream raw materials:

(+)-{(1S,4S,5S)-4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]-hept-2-en-2-yl}methanol

N-(+)-biotinyl-6-aminocaproic acid