2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

Base Information

Chemical Name:2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline
CAS No.:1621622-63-6
Molecular Formula:C₂₄H₂₂N₄
Molecular Weight:366.465
Hs Code.:

Synonyms:2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

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Chemical Property of 2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

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Technology Process of 2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

There total 7 articles about 2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)vinyl)pyrazolo[5,1-a]isoquinoline

: 1621622-63-6
2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.07.020

Reference yield:

: C₂₁H₂₂N₂O₃S

: 1621622-63-6
2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / 12 h / 20 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

3: Dess-Martin periodane / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -5 °C

5: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

With boron tribromide; sodium hydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; 4: |Wittig Olefination;
DOI:10.1016/j.ejmech.2014.07.020

Reference yield:

: 1621622-78-3
5-(methoxymethyl)-2-methylpyrazolo[5,1-a]isoquinoline

: 1621622-63-6
2-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -5 °C

4: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

With boron tribromide; sodium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; 3: |Wittig Olefination;
DOI:10.1016/j.ejmech.2014.07.020