methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate
CAS No.:1415323-21-5
Molecular Formula:C₃₁H₃₁BrN₂O₃
Molecular Weight:559.503
Hs Code.:

Synonyms:methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

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Chemical Property of methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

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Technology Process of methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

There total 6 articles about methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415323-20-4
1-(4-(1-(methoxycarbonyl)cyclopropyl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

: 74877-08-0,139305-96-7
(S)-1-(3-bromophenyl)ethanamine

: 1415323-21-5
methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 959632-00-9
methyl 1-(p-tolyl)cyclopropanecarboxylate

: 1415323-21-5
methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-Bromosuccinimide; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 873372-30-6
methyl 1-(4-(bromomethyl)phenyl)cyclopropanecarboxylate

: 1415323-21-5
methyl (S)-1-(4-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; mineral oil;