(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Base Information

Chemical Name:(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester
CAS No.:914452-42-9
Molecular Formula:C₂₉H₃₈N₂O₇
Molecular Weight:526.63
Hs Code.:

Synonyms:(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

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Technology Process of (S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

There total 5 articles about (S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 914382-65-3
(S)-4-bromo-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

: 75383-60-7
(4-hydroxy-benzyl)carbamic acid benzyl ester

: 914452-42-9
(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 18h;

Reference yield:

: 191655-45-5
(2S)‐2‐{[(tert‐butoxy)carbonyl]amino}‐4‐[(tert‐butyldimethylsilyl)oxy]butanoic acid

: 914452-42-9
(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2: water; acetic acid / tetrahydrofuran / 16 h / 30 °C

3: pyridine; N-Bromosuccinimide; triphenylphosphine / dichloromethane / 18.08 h

4: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C

With pyridine; dmap; N-Bromosuccinimide; water; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 914452-42-9
(S)-4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

3: water; acetic acid / tetrahydrofuran / 16 h / 30 °C

4: pyridine; N-Bromosuccinimide; triphenylphosphine / dichloromethane / 18.08 h

5: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C

With pyridine; dmap; N-Bromosuccinimide; water; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;