(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

Base Information

Chemical Name:(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide
CAS No.:1384459-26-0
Molecular Formula:C₁₉H₂₀N₂O₂S
Molecular Weight:340.446
Hs Code.:

Synonyms:(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

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Technology Process of (R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

There total 4 articles about (R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1384459-25-9
(R)-N-(prop-2-yn-1-yl)-1-(pyridin-2-yl)but-3-en-1-amine

: 98-59-9
p-toluenesulfonyl chloride

: 1384459-26-0
(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.04.016

Reference yield:

: 17285-57-3,144635-02-9,517907-57-2
1-(2-pyridinyl)but-3-en-1-ol

: 1384459-26-0
(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: PS-C Amano II lipase / tetrahydrofuran / 30 h / 24 °C / Resolution of racemate; Enzymatic reaction

2: triethylamine / dichloromethane / 0 °C / Inert atmosphere

3: potassium carbonate / 24 h / 20 °C / Neat (no solvent); Inert atmosphere

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With PS-C Amano II lipase; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.04.016

Reference yield:

: 1384459-24-8
C₁₀H₁₃NO₃S

: 1384459-26-0
(R)-4-methyl-N-(prop-2-yn-1-yl)-N-(1-(pyridin-2-yl)but-3-en-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 24 h / 20 °C / Neat (no solvent); Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In dichloromethane;
DOI:10.1016/j.tetasy.2012.04.016