C₆₄H₇₈N₅O₉P

Base Information

• Chemical Name: C₆₄H₇₈N₅O₉P
• CAS No.: 1257063-27-6
• Molecular Formula: C₆₄H₇₈N₅O₉P
• Molecular Weight: 1092.33
• Mol file: 1257063-27-6.mol

Synonyms:C₆₄H₇₈N₅O₉P

Chemical Property of C₆₄H₇₈N₅O₉P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₄H₇₈N₅O₉P

There total 10 articles about C₆₄H₇₈N₅O₉P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C55H61N3O8 (1257063-26-5) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → C64H78N5O9P (1257063-27-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ol102205j

Reference yield:

5,6,11,12-tetrahydro-5,11-epoxydibenzocyclooctene (77733-39-2,66365-45-5) → C64H78N5O9P (1257063-27-6)

Guidance literature:

Multi-step reaction with 9 steps

1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice; Inert atmosphere

3: bromine / chloroform / 0.67 h / 0 - 4 °C / Cooling with ice

4: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 20 °C

5: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 20 °C

7: lithium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

9: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With 1H-imidazole; n-butyllithium; water; bromine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

C17H17BrO → C64H78N5O9P (1257063-27-6)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 20 °C

2: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 20 °C

4: lithium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

C₅₅H₆₁N₃O₈

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

phenylacetaldehyde

5,6,11,12-tetrahydro-5,11-epoxydibenzocyclooctene