[4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester

Base Information

• Chemical Name: [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester
• CAS No.: 890137-55-0
• Molecular Formula: C₁₇H₁₆Br₂O₄
• Molecular Weight: 444.12
• Mol file: 890137-55-0.mol

Synonyms:[4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester

Chemical Property of [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester

There total 4 articles about [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,2-dibromo-4-(bromomethyl)benzene (64382-93-0) + methyl (4-hydroxy-2-methylphenoxy)acetate (317319-10-1) → [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester (890137-55-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2006.02.079

Reference yield:

4-hydroxy-3-methylphenyl methyl ketone (876-02-8) → [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester (890137-55-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Cs₂CO₃ / acetonitrile / 20 °C

2: meta-chloroperbenzoic acid; p-TsOH / CH₂Cl₂ / 48 h / Heating

3: MeONa / methanol / 1 h / 20 °C

4: 64 percent / Cs₂CO₃ / acetonitrile / 18 h / 20 °C

With sodium methylate; caesium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.02.079

Reference yield:

(4-acetyl-2-methylphenoxy)acetic acid methyl ester (166953-80-6) → [4-(3,4-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester (890137-55-0)

Guidance literature:

Multi-step reaction with 3 steps

1: meta-chloroperbenzoic acid; p-TsOH / CH₂Cl₂ / 48 h / Heating

2: MeONa / methanol / 1 h / 20 °C

3: 64 percent / Cs₂CO₃ / acetonitrile / 18 h / 20 °C

With sodium methylate; caesium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.02.079

upstream raw materials:

1,2-dibromo-4-(bromomethyl)benzene

methyl (4-hydroxy-2-methylphenoxy)acetate

4-hydroxy-3-methylphenyl methyl ketone

(4-acetyl-2-methylphenoxy)acetic acid methyl ester

Downstream raw materials:

[4-(3,4-bis(4-methoxyphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

[4-(4,4''-bis-trifluoromethyl-[1,1';2',1'']terphenyl-4'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester

[4-(4,4''-bis-trifluoromethoxy-[1,1';2',1'']terphenyl-4'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester