2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Base Information

Chemical Name:2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid
CAS No.:937054-42-7
Molecular Formula:C₂₅H₂₃ClFN₅O₅
Molecular Weight:527.94
Hs Code.:

Synonyms:2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

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Chemical Property of 2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

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Technology Process of 2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

There total 12 articles about 2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-38-1
ethyl 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetate

: 937054-42-7
2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: With potassium carbonate;

Reference yield:

: 937057-59-5
1-(2-Bromo-4-chloro-6-fluorophenyl)-1H-pyrrole

: 937054-42-7
2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.25 h / -78 - 0 °C

1.2: 1 h / -78 - 0 °C

2.1: manganese(IV) oxide / dichloromethane / 14 h / 20 °C / Heating / reflux

3.1: trichlorophosphate / 0.25 h / 0 - 20 °C

3.2: 2.08 h / 0 - 50 °C

3.3: 0.5 h / 50 °C

4.1: toluene / 1 h / Heating / reflux

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

5.2: 0 °C

6.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

7.1: Resolution of racemate

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

8.2: 0 °C

9.1: triethylamine / dichloromethane / 1 h / 0 °C

10.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

11.1: potassium carbonate

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 937057-62-0
1-[4-Chloro-2-(2,3-dimethoxybenzoyl)-6-fluorophenyl]-1H-pyrrolo-2-carbaldehyde

: 937054-42-7
2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 1 h / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

2.2: 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

4.1: Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

5.2: 0 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

8.1: potassium carbonate

With sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; triethylamine; trifluoroacetic acid; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;