(S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride

Base Information

• Chemical Name: (S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride
• CAS No.: 125739-24-4
• Molecular Formula: C₃₀H₅₂N₁₀O₇*ClH
• Molecular Weight: 701.267

Synonyms:(S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride

Chemical Property of (S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride

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Technology Process of (S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride

There total 8 articles about (S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C76H89N9O13 → (S)-N1-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride (125739-24-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1016/S0040-4039(01)80392-0

Reference yield:

3-[(4-Amino-butyl)-benzyl-amino]-propionic acid (125718-83-4) → (S)-N1-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride (125739-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / dimethylformamide

2: 54.9 percent / DEC, HOBt, TEA / dimethylformamide

3: 53 percent / H₂ / Pd/C / acetic acid

With diethylcarbamazine; TEA; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)80392-0

Reference yield:

[5-((S)-2-Amino-3-carbamoyl-propionylamino)-pentyl]-carbamic acid tert-butyl ester (125718-80-1) → (S)-N1-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride (125739-24-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / dimethylformamide

2: 71 percent / HCl / dioxane

3: 54.9 percent / DEC, HOBt, TEA / dimethylformamide

4: 53 percent / H₂ / Pd/C / acetic acid

With hydrogenchloride; diethylcarbamazine; TEA; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)80392-0

upstream raw materials:

3-[(4-Amino-butyl)-benzyl-amino]-propionic acid

[5-((S)-2-Amino-3-carbamoyl-propionylamino)-pentyl]-carbamic acid tert-butyl ester

3-{Benzyl-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-amino}-propionitrile

[5-((S)-2-Benzyloxycarbonylamino-3-carbamoyl-propionylamino)-pentyl]-carbamic acid tert-butyl ester

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