1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

Base Information

Chemical Name:1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea
CAS No.:1637586-82-3
Molecular Formula:C₂₀H₂₄FN₃O₄S
Molecular Weight:421.493
Hs Code.:

Synonyms:1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

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Chemical Property of 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

Chemical Property:

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Technology Process of 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

There total 7 articles about 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

: 1637586-78-7
4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)aniline

: 109-90-0
ethyl isocyanate

: 1637586-82-3
1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.3390/molecules19056163

Reference yield:

: 138227-62-0
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

: 1637586-82-3
1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

3: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

4: dichloromethane / 20 °C

With dmap; tin(II) chloride dihdyrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163

Reference yield:

: 1637586-76-5
C₁₇H₁₇FN₂O₅S

: 1637586-82-3
1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

2: dichloromethane / 20 °C

With tin(II) chloride dihdyrate; In ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163