[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

Base Information

Chemical Name:[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol
CAS No.:205868-40-2
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

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Chemical Property of [(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

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Technology Process of [(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

There total 13 articles about [(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 205868-37-7
{(2R,4R,5S,6R)-4-[(S)-1-(2,5-Dimethoxy-phenyl)-1-hydroxy-ethyl]-2-phenyl-6-vinyl-[1,3]dioxan-5-yl}-methyl-carbamic acid methyl ester

: 205868-40-2
[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 8h; Heating;
DOI:10.1080/07328309808002322

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 205868-40-2
[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / p-TsOH / CH₂Cl₂ / 14 h / Ambient temperature

2: 96 percent / I₂, aq. NaHCO₃ / acetone / 6 h / Ambient temperature

3: 41 percent / n-BuLi / tetrahydrofuran / -60 - 20 °C

4: 78 percent / PDC, Ac₂O / CH₂Cl₂ / 3 h / Ambient temperature

5: tetrahydrofuran / -90 °C

6: 76 percent / LAH / diethyl ether / 8 h / Heating

With lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; iodine; acetic anhydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;
DOI:10.1080/07328309808002322

Reference yield:

: 205868-31-1
[(1S)-(2,2-bis-ethylsulfanyl-(1R)-hydroxyethyl)-(2R)-hydroxybut-3-enyl]-methylcarbamic acid methyl ester

: 205868-40-2
[(1S)-(2,5-dimethoxyphenyl)]-1-((5S)-dimethylamino-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(4R)-yl)-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / p-TsOH / CH₂Cl₂ / 14 h / Ambient temperature

2: 96 percent / I₂, aq. NaHCO₃ / acetone / 6 h / Ambient temperature

3: 41 percent / n-BuLi / tetrahydrofuran / -60 - 20 °C

4: 78 percent / PDC, Ac₂O / CH₂Cl₂ / 3 h / Ambient temperature

5: tetrahydrofuran / -90 °C

6: 76 percent / LAH / diethyl ether / 8 h / Heating

With lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; iodine; acetic anhydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;
DOI:10.1080/07328309808002322