(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Base Information

Chemical Name:(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate
CAS No.:1447498-23-8
Molecular Formula:C₂₀H₁₈N₄O₃
Molecular Weight:362.388
Hs Code.:

Synonyms:(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Suppliers and Price of (S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

There total 5 articles about (S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₂₃H₂₁N₅O₃

: 109-77-3
malononitrile

: 1447498-23-8
(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃; for 0.5h; Microwave irradiation;
DOI:10.1002/ejoc.201201731

Reference yield:

: 154006-07-2
(S)-2-(2-((benzyloxy)carbonyl)hydrazinyl)-3-phenylpropanoic acid

: 1447498-23-8
(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / -10 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 60 °C / Microwave irradiation

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201201731

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1447498-23-8
(S)-benzyl 2-(4,4-dicyano-3-oxo-1-phenylbutan-2-yl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium bromide; sodium nitrite; sulfuric acid / 6 h / -10 °C

2: hydrazine hydrate / ethanol / 70 °C / Microwave irradiation

3: triethylamine / water; acetonitrile / 20 °C

4: thionyl chloride / dichloromethane / 4 h / -10 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 60 °C / Microwave irradiation

With thionyl chloride; sulfuric acid; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium bromide; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ejoc.201201731