N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide
• CAS No.: 160878-28-4
• Molecular Formula: C₁₅H₁₇NO₃S
• Molecular Weight: 291.371
• NSC Number: 406164
• DSSTox Substance ID: DTXSID701252083
• Mol file: 160878-28-4.mol

Synonyms:N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide;160878-28-4;benzenesulfonamide, N-(2-ethoxyphenyl)-4-methyl-;NSC406164;N-(2-Ethoxy-phenyl)-4-methyl-benzenesulfonamide;Oprea1_271455;Oprea1_549600;SCHEMBL8752535;DTXSID701252083;STL062478;AKOS000383149;NSC-406164;EU-0035973;AN-329/11634525;SR-01000410443;SR-01000410443-1;Z45704606

Chemical Property of N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide

Chemical Property:

• Melting Point: 153.4 °C
• Boiling Point: 435.1±55.0 °C(Predicted)
• PKA: 8.96±0.10(Predicted)
• Density: 1.238±0.06 g/cm3(Predicted)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 291.09291458
• Heavy Atom Count: 20
• Complexity: 382

Purity/Quality:

N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)C

Technology Process of N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide

There total 1 articles about N-(2-ethoxyphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + ortho-phenitidine (94-70-2) → toluene-4-sulfonic acid o-phenetidide (160878-28-4)

Guidance literature:

With pyridine;

Reference yield:

toluene-4-sulfonic acid o-phenetidide (160878-28-4) → 5-nitro-2-amino-phenetole (16383-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: water; nitric acid

2: sulfuric acid

With sulfuric acid; water; nitric acid;

Reference yield:

toluene-4-sulfonic acid o-phenetidide (160878-28-4) → toluene-4-sulfonic acid-(2-ethoxy-4-nitro-anilide) (324053-01-2)

Guidance literature:

With water; nitric acid;

upstream raw materials:

p-toluenesulfonyl chloride

ortho-phenitidine

Downstream raw materials:

toluene-4-sulfonic acid-(2-ethoxy-4-nitro-anilide)

5-nitro-2-amino-phenetole