vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Base Information

Chemical Name:vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate
CAS No.:85923-44-0
Molecular Formula:C₂₅H₂₆N₂O₅S
Molecular Weight:466.558
Hs Code.:

Synonyms:vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Chemical Property of vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Technology Process of vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

There total 5 articles about vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 85923-43-9
2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

: 85923-44-0
vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -15 ℃; for 0.333333h;
DOI:10.1021/ja00352a037

Reference yield:

: 5416-80-8
2-methyl-1H-indole-3-carbaldehyde

: 85923-44-0
vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: 2.) Na₂SO₄ / 1.) benzene, 1 h, 2.) 2 h

3: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

4: 90 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h / -15 °C

With 1H-imidazole; potassium tert-butylate; sodium hydride; sodium sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chlorobenzene;
DOI:10.1021/ja00352a037

Reference yield:

: 80664-26-2
N-<(4-methoxyphenyl)sulfonyl>-2-methylindole-3-carboxaldehyde

: 85923-44-0
vinyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) Na₂SO₄ / 1.) benzene, 1 h, 2.) 2 h

2: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

3: 90 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h / -15 °C

With potassium tert-butylate; sodium sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chlorobenzene;
DOI:10.1021/ja00352a037