(1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide

Base Information

• Chemical Name: (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide
• CAS No.: 872047-94-4
• Molecular Formula: C₂₃H₃₄N₂O₅S₂
• Molecular Weight: 482.665

Synonyms:(1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide

Chemical Property of (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide

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Technology Process of (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide

There total 4 articles about (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Camphorsulfonyl chloride (21286-54-4) + (1R,2R)-(-)-N-p-tosyl-1,2-cyclohexanediamine (174291-96-4,58825-94-8) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide (872047-94-4)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 ℃; for 24h;

DOI:10.1016/j.tetasy.2005.08.031

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide (872047-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / CH₂Cl₂ / 6 h / 0 - 25 °C

2: DMAP; Et₃N / acetonitrile / 24 h / 0 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/chem.200501397

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methylbenzenesulfonamide (872047-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / CH₂Cl₂ / 6 h / 0 - 25 °C

2: DMAP; Et₃N / acetonitrile / 24 h / 0 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/chem.200501397

upstream raw materials:

Camphorsulfonyl chloride

(1R,2R)-(-)-N-p-tosyl-1,2-cyclohexanediamine

(1R,2R)-1,2-diaminocyclohexane

p-toluenesulfonyl chloride

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