3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

Base Information

Chemical Name:3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol
CAS No.:1378432-75-7
Molecular Formula:C₁₅H₂₄BrClO₂Si
Molecular Weight:379.797
Hs Code.:

Synonyms:3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

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Chemical Property of 3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

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Technology Process of 3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

There total 1 articles about 3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1378432-73-5
{[1-(2-bromo-6-chlorophenyl)-2-propen-1-yl]oxy}(1,1-dimethylethyl)dimethylsilane

: 1378432-75-7
3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

Guidance literature:: {[1-(2-bromo-6-chlorophenyl)-2-propen-1-yl]oxy}(1,1-dimethylethyl)dimethylsilane; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 20 ℃;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1.5h;

Reference yield: 91.0%

: 1378432-75-7
3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

: 1378432-78-0
{[3-bromo-1-(2-bromo-6-chlorophenyl)propyl]oxy}(1,1-dimethylethyl)dimethylsilane

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 1378432-75-7
3-(2-bromo-6-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-propanol

: 1378428-27-3
6-[[2-(4-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)ethyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 1.5 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 22 h / 75 - 85 °C

3: hydrogenchloride / water; tetrahydrofuran / 23 h / 20 °C / Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 40 h / 45 - 53 °C

5: potassium acetate; sodium bromide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 64 h / 85 °C

6: hydrogenchloride / water; tetrahydrofuran / 16 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;