4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

Base Information

Chemical Name:4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide
CAS No.:1246085-06-2
Molecular Formula:C₂₄H₃₀N₄O₄
Molecular Weight:438.527
Hs Code.:

Synonyms:4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

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Chemical Property of 4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

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Technology Process of 4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

There total 9 articles about 4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N,3-dimethyl-4-(piperazin-1-yl)benzamide dihydrochloride

: 1246081-95-7
8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde

: 1246085-06-2
4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 23 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1246085-06-2
4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 16 h / 140 °C

2: tetrahydrofuran; methanol / 18.25 h / 10 - 23 °C

3: sodium hydroxide / ethanol; water / 10 h / 90 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 23 °C

5: hydrogenchloride / 1,4-dioxane / 0.5 h / 23 °C

6: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 851000-32-3
3-methyl-4-(piperazin-1-yl)benzonitrile

: 1246085-06-2
4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; methanol / 18.25 h / 10 - 23 °C

2: sodium hydroxide / ethanol; water / 10 h / 90 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 23 °C

4: hydrogenchloride / 1,4-dioxane / 0.5 h / 23 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055