3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

Base Information

Chemical Name:3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine
CAS No.:666724-45-4
Molecular Formula:C₃₇H₄₇N₃O₆SeSi
Molecular Weight:736.842
Hs Code.:

Synonyms:3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

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Chemical Property of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

Chemical Property:

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Technology Process of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

There total 4 articles about 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666724-44-3
2,4,6-Triisopropyl-benzenesulfonic acid 1-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methylselanyl-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 666724-45-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja038481k

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 666724-45-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / pyridine / 20 °C

2: 92 percent / sodium borohydride / tetrahydrofuran; ethanol / 2 h / 20 °C

3: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

4: DMAP; triethylamine / CH₂Cl₂ / 1 h / 20 °C

5: 395 mg / aq. ammonia / tetrahydrofuran / 20 °C

With pyridine; 1H-imidazole; dmap; ammonium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja038481k

Reference yield:

: 393802-82-9
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methoxyuridine

: 666724-45-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: DMAP; triethylamine / CH₂Cl₂ / 1 h / 20 °C

3: 395 mg / aq. ammonia / tetrahydrofuran / 20 °C

With 1H-imidazole; dmap; ammonium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja038481k