6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

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Chemical Name:6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one
CAS No.:1021916-54-0
Molecular Formula:C₁₉H₁₉N₇O₂
Molecular Weight:377.406
Hs Code.:

Synonyms:6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

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Chemical Property of 6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

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Technology Process of 6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

There total 7 articles about 6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1021916-46-0
4-(2-oxo-3-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-5-yl)benzamide

: 4909-78-8
N,N-dimethylformamide dineopentyl acetal

: 1021916-54-0
6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

Guidance literature:: 4-(2-oxo-3-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-5-yl)benzamide; N,N-dimethylformamide dineopentyl acetal; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

With acetic acid; hydrazine; for 1.5h;

Reference yield:

: 1021920-29-5
C₂₁H₂₄N₆O₃

: 1021916-54-0
6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

Guidance literature:: With acetic acid; hydrazine; for 1.5h;
DOI:10.1016/j.bmcl.2011.09.035

Reference yield:

: 130290-79-8
4-tetrahydropyranmethylamine

: 1021916-54-0
6-(4-(4H-1,2,4-triazol-3-yl)phenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo [4,5-b]pyrazin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: butan-1-ol / 120 - 130 °C

2: tetrahydrofuran / 95 - 100 °C

3: potassium dihydrogenphosphate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / water; N,N-dimethyl-formamide / 85 - 95 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 1.5 h / 80 °C

5: acetic acid; hydrazine / 1.5 h

With potassium dihydrogenphosphate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; acetic acid; hydrazine; In tetrahydrofuran; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2011.09.035