2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

Base Information

Chemical Name:2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide
CAS No.:1370349-53-3
Molecular Formula:C₃₈H₃₆N₂O₆S
Molecular Weight:648.78
Hs Code.:

Synonyms:2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

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Chemical Property of 2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

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Technology Process of 2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

There total 5 articles about 2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 102-32-9
3,4-dihydroxyphenylacetate

: 1370349-51-1
2-amino-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

: 1370349-53-3
2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.02.018

Reference yield:

: 76-84-6
triphenylmethyl alcohol

: 1370349-53-3
2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / 2 h

1.2: 0 °C / pH 5 - 6

2.1: sodium hydroxide / water / 24 h / 20 °C

2.2: pH 2

3.1: dicyclohexyl-carbodiimide / acetonitrile / 14 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: trifluoroacetic acid / water / 3 h

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12.5 h / 0 - 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.02.018

Reference yield:

: 2799-07-7
S-trityl-L-cysteine

: 1370349-53-3
2-[2-(3,4-dihydroxyphenyl)acetylamino]-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(tritylsulfanyl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 24 h / 20 °C

1.2: pH 2

2.1: dicyclohexyl-carbodiimide / acetonitrile / 14 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: trifluoroacetic acid / water / 3 h

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12.5 h / 0 - 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.02.018