Naphazoline nitrate

Base Information

• Chemical Name: Naphazoline nitrate
• CAS No.: 5144-52-5
• Molecular Formula: C14H14N2^.HNO3
• Molecular Weight: 273.32
• Hs Code.: 29332900
• European Community (EC) Number: 233-197-9,225-915-4
• UNII: SC99GR1T5S
• DSSTox Substance ID: DTXSID60863496
• Wikidata: Q27289139
• NCI Thesaurus Code: C98243
• Mol file: 5144-52-5.mol

Synonyms:Afazol Grin;AK Con;AK-Con;Albalon;All Clear;Clear Eyes;Colirio Alfa;Hydrochloride, Naphazoline;Idril;Miraclar;Monohydrochloride, Naphazoline;Nafazair;Naphazoline;Naphazoline Hydrochloride;Naphazoline Monohydrochloride;Naphazoline Nitrate;Naphcon;Naphcon forte;Nitrate, Naphazoline;Optazine;Pensa, Vasoconstrictor;Privin;Privine;Proculin;Siozwo;Tele Stulln;Tele-Stulln;Vasoclear;Vasocon;Vasocon Regular;Vasoconstrictor Pensa;VasoNit

Chemical Property of Naphazoline nitrate

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 5.73E-12mmHg at 25°C
• Melting Point: 167-170 °C
• Boiling Point: 440.5 °C at 760 mmHg
• Flash Point: 220.2 °C
• PSA: 90.44000
• LogP: 2.32390
• Sensitive.: Hygroscopic
• Solubility.: Sparingly soluble in water, soluble in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 273.11134135
• Heavy Atom Count: 20
• Complexity: 297

Purity/Quality:

99% ^*data from raw suppliers

Naphazoline nitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-36/37-60-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.[N+](=O)(O)[O-]
• Indications: Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion. Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma. Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).