cytoblastin

Base Information

• Chemical Name: cytoblastin
• CAS No.: 137109-42-3
• Molecular Formula: C₂₈H₃₄N₄O₄
• Molecular Weight: 490.602
• Mol file: 137109-42-3.mol

Synonyms:3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one,9-[2,3-dihydroxy-1-(1H-indol-3-yl)propyl]-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-,[2S-[2R*,5R*,9(1R*,2R*)]]-; Cytoblastin; Cytoblastine; NSC 654239

Chemical Property of cytoblastin

Chemical Property:

• Vapor Pressure: 9.25E-33mmHg at 25°C
• Boiling Point: 875.2°C at 760 mmHg
• Flash Point: 483.1°C
• PSA: 128.10000
• Density: 1.292g/cm³
• LogP: 2.96920

Purity/Quality:

CYTOBLASTIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cytoblastin

There total 2 articles about cytoblastin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(10S,13S)-5-{2,3-Dihydroxy-1-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indol-3-yl]-propyl}-13-hydroxymethyl-10-isopropyl-9-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,9,12-triaza-tricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one → cytoblastin (137109-42-3)

Guidance literature:

With tetrabutyl ammonium fluoride; neat, at 0.1 Torr;

DOI:10.1016/S0968-0896(98)00113-8

Reference yield:

(10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5-{1-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indol-3-yl]-allyl}-3-(2-trimethylsilanyl-ethoxymethyl)-3,9,12-triaza-tricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one → cytoblastin (137109-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / OsO₄; TMEDA; 1,3-propanedithiol / CH₂Cl₂ / -90 - 20 °C

2: 90 percent / Bu₄NF / neat, at 0.1 Torr

With 1.3-propanedithiol; osmium(VIII) oxide; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; In dichloromethane; 1: Oxidation / 2: Deprotection;

DOI:10.1016/S0968-0896(98)00113-8