(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester
CAS No.:431059-48-2
Molecular Formula:C₂₆H₄₃N₃O₆
Molecular Weight:493.644
Hs Code.:

(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

Synonyms:(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

There total 2 articles about (S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 2491-20-5
L-alanine methyl ester hydrochloride

: 431063-61-5
Boc-PheψLeu-OMe

: 431059-48-2
(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

: 431059-49-3
(S)-2-{(1R,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

: [(S)-1-((S)-6-Isobutyl-5-oxo-piperazin-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 8h; under 760 Torr;
DOI:10.1021/jo0256336

Reference yield:

: 2491-20-5
L-alanine methyl ester hydrochloride

: 431063-61-5
Boc-PheψLeu-OMe

: [(S)-1-((2S,6S)-6-Isobutyl-5-oxo-piperazin-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: [(S)-1-((2R,6S)-6-Isobutyl-5-oxo-piperazin-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 431059-48-2
(S)-2-{(1S,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

: 431059-49-3
(S)-2-{(1R,2S)-2-tert-Butoxycarbonylamino-1-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-3-phenyl-propylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; at 20 ℃; for 8h; under 760 Torr; Further Variations:; Catalysts; Temperatures; Solvents; Product distribution;
DOI:10.1016/S0040-4039(02)00012-6