N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide

Base Information

• Chemical Name: N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide
• CAS No.: 1027223-34-2
• Molecular Formula: C₁₉H₁₄N₄O₃S
• Molecular Weight: 378.411

Synonyms:N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide

Chemical Property of N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide

Chemical Property:

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Technology Process of N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide

There total 3 articles about N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide (1027223-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide (1027223-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

2-thienylacetic acid chloride (39098-97-0) + 5(6)-nitro 2-(4-aminophenyl)-1H-benzimidazole (71002-88-5) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide (1027223-34-2)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

2-thienylacetic acid chloride

5⁽⁶⁾-nitro 2-(4-aminophenyl)-1H-benzimidazole

4-amino-benzoic acid

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

N-[4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-2-thiophen-2-yl-acetamide

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