3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Base Information

Chemical Name:3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil
CAS No.:1296176-95-8
Molecular Formula:C₄₀H₃₀ClFN₄O₁₀
Molecular Weight:781.15
Hs Code.:

Synonyms:3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

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Technology Process of 3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

There total 10 articles about 3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1296176-95-8
3-{3-[4-(2,6-dibenzyloxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere; Cooling

2: thionyl chloride / N,N-dimethyl-formamide / toluene / 4.5 h / 80 °C

3: triethylamine / 1,4-dioxane / 8 h / 20 °C / Cooling with ice

With thionyl chloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;