3-[8'-quinolinylamino]cyclohex-2-en-1-one

Base Information

Chemical Name:3-[8'-quinolinylamino]cyclohex-2-en-1-one
CAS No.:271778-95-1
Molecular Formula:C₁₅H₁₄N₂O
Molecular Weight:238.289
Hs Code.:

Synonyms:3-[8'-quinolinylamino]cyclohex-2-en-1-one

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Chemical Property of 3-[8'-quinolinylamino]cyclohex-2-en-1-one

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Technology Process of 3-[8'-quinolinylamino]cyclohex-2-en-1-one

There total 1 articles about 3-[8'-quinolinylamino]cyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 578-66-5
8-amino quinoline

: 504-02-9
1,3-cylohexanedione

: 271778-95-1
3-[8'-quinolinylamino]cyclohex-2-en-1-one

Guidance literature:: With ytterbium(III) triflate; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.joc.8b03144

Reference yield: 58.0%

: 79-22-1
methyl chloroformate

: 271778-95-1
3-[8'-quinolinylamino]cyclohex-2-en-1-one

: methyl N-(3-oxocyclohex-1-en-1-yl)-N-(quinolin-8-yl)carbamate

Guidance literature:: 3-[8'-quinolinylamino]cyclohex-2-en-1-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/acs.joc.8b03144

Reference yield:

: 271778-95-1
3-[8'-quinolinylamino]cyclohex-2-en-1-one

: 578-66-5
8-amino quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / toluene / 2 h / Heating

1.2: 72 percent / toluene / 2 h / Heating

2.1: 8 percent / methanol / 0.5 h / UV-irradiation; 254 nm

With sodium hydride; In methanol; toluene; 1.1: deprotonation / 1.2: benzylation / 2.1: homolysis;
DOI:10.3987/COM-99-8837