(2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride

Base Information

• Chemical Name: (2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride
• CAS No.: 51226-17-6
• Molecular Formula: C₅H₄ClNO₃S
• Molecular Weight: 193.611
• DSSTox Substance ID: DTXSID401279006
• Mol file: 51226-17-6.mol

Synonyms:(2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride;51226-17-6;2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetyl chloride;(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)ACETYL CHLORIDE;DTXSID401279006;BCA22617;AKOS000268064;2,4-Dioxo-5-thiazolidineacetyl chloride;2,4-dioxothiazolidine-5-acetyl chloride;(2,4-Dioxo-1,3-thiazolidin-5-yl)acetyl chloride, AldrichCPR

Chemical Property of (2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.9600419
• Heavy Atom Count: 11
• Complexity: 230

Purity/Quality:

98%min ^*data from raw suppliers

(2,4-Dioxo-thiazolidin-5-yl)-acetylchloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(=O)NC(=O)S1)C(=O)Cl

Technology Process of (2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride

There total 1 articles about (2,4-Dioxo-thiazolidin-5-yl)-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,4-dioxothiazolidin-5-yl)acetic acid (875-97-8) → 2-(2,4-dioxothiazolidin-5-yl)acetic acid chloride (51226-17-6)

Guidance literature:

With thionyl chloride;

Reference yield: 81.0%

2-(2,4-dioxothiazolidin-5-yl)acetic acid chloride (51226-17-6) + 2-(9-(4-chlorophenyl)-3,7-dithia-5-azatetracyclo[9.2.1.02,10.04,8]tetradec-4(8)-en-6-one-5-yl)acetic acid hydrazide → dihydrazide of 2-(9-(4-chlorophenyl)-3,7-dithia-5-azatetracyclo[9.2.1.02,10.04,8]tetradec-4(8)-en-6-one-5-yl)acetic acid and 2,4-thiazolidinedione-5-acetic acid

Guidance literature:

With triethylamine; In 1,4-dioxane; at 80 ℃; for 0.25h;

DOI:10.7124/bc.00094F

Reference yield: 72.0%

5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione (52036-16-5) + 2-(2,4-dioxothiazolidin-5-yl)acetic acid chloride (51226-17-6) → 4-[(2,5-dioxoimidazolidin-4-ylidene)methyl]-2-methoxyphenyl (2,4-dioxo-1,3-thiazolidin-5-yl)acetate

Guidance literature:

With pyridine; In 1,4-dioxane; for 2h;

DOI:10.3390/molecules23051023

upstream raw materials:

2-(2,4-dioxothiazolidin-5-yl)acetic acid

Downstream raw materials:

1-[(2,4-dioxothiazolidin-5-yl)acetyl]-4-phenyl-5-thioxo-4,5-dihydro-1,2,4-triazole

1-[(2,4-dioxothiazolidin-5-yl)acetyl]-5-oxo-4-phenyl-4,5-dihydro-1,2,4-triazole

N-(thiazol-2-yl)-2-(2,4-dioxothiazolidin-5-yl)acetamide

2-(2,4-dioxo-thiazolidin-5-yl)-N-(4-sulfamoyl-phenyl)-acetamide