Colchicine, 17,17,17-trifluoro-

Base Information

Chemical Name:Colchicine, 17,17,17-trifluoro-
CAS No.:26195-65-3
Molecular Formula:C₂₂H₂₂F₃NO₆
Molecular Weight:453.415
Hs Code.:
NSC Number:305987
DSSTox Substance ID:DTXSID90180825
Nikkaji Number:J67.649G
ChEMBL ID:CHEMBL83406
Mol file:26195-65-3.mol

Synonyms:N-Trifluoroacetyl Deacetylcolchicine;26195-65-3;COLCHICINE, 17,17,17-TRIFLUORO-;NSC 305987;N-Deacetyl-N-(trifluoroacetyl)colchicine;17,17,17-Trifluorocolchicine;BRN 3021687;2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide;NSC305987;CHEMBL83406;C22H22F3NO6;DTXSID90180825;C22-H22-F3-N-O6;N-Trifluoroacetyl-N-deacetylcolchicine;NSC-305987;LS-54692;Acetamide,2,2-trifluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-

Suppliers and Price of Colchicine, 17,17,17-trifluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-TrifluoroacetylDeacetylcolchicine
500mg
$ 1320.00

American Custom Chemicals Corporation
N-TRIFLUOROACETYL DEACETYLCOLCHICINE 98.00%
500MG
$ 1686.30

American Custom Chemicals Corporation
N-TRIFLUOROACETYL DEACETYLCOLCHICINE 98.00%
50MG
$ 716.10

Total 5 raw suppliers

Chemical Property of Colchicine, 17,17,17-trifluoro-

Chemical Property:

Vapor Pressure:2.05E-18mmHg at 25°C
Boiling Point:681.3°C at 760 mmHg
PKA:9.68±0.40(Predicted)
Flash Point:365.8°C
PSA：83.09000
Density:1.36g/cm³
LogP:3.80490
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:453.13992191
Heavy Atom Count:32
Complexity:834

Purity/Quality:

99% ^*data from raw suppliers

N-TrifluoroacetylDeacetylcolchicine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)C(F)(F)F
Isomeric SMILES:COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)C(F)(F)F
Uses An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and t umor cell lines and activates the JNK/SAPK signaling pathway. An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Technology Process of Colchicine, 17,17,17-trifluoro-

There total 7 articles about Colchicine, 17,17,17-trifluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3476-50-4
deacetylcolchicine

: 407-25-0
trifluoroacetic anhydride

: 26195-65-3
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo heptalen-7-yl)-(S)-2,2,2-trifluoroacetamide

Guidance literature:: With sodium carbonate; In diethyl ether; for 2.5h; Ambient temperature;
DOI:10.1021/jo00363a021

Reference yield:

: 73307-44-5,68296-64-0
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

: 26195-65-3
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo heptalen-7-yl)-(S)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

2: 46 percent / methanol; diethyl ether / 3 h

3: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

5: 75 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

With sodium carbonate; potassium carbonate; In methanol; diethyl ether; water; acetone;
DOI:10.1021/jo00363a021

Reference yield:

: 209810-38-8,54192-66-4
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide

: 26195-65-3
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo heptalen-7-yl)-(S)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / 20percent H₂SO₄ / acetic acid / 5 h / 80 - 90 °C

2: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

3: 46 percent / methanol; diethyl ether / 3 h

4: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

6: 75 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

With sulfuric acid; sodium carbonate; potassium carbonate; In methanol; diethyl ether; water; acetic acid; acetone;
DOI:10.1021/jo00363a021