Technology Process of N-benzyl-N-(trifluoromethanesulfonyl)-(phenylsulfanyl)difluoromethanesulfonamide
There total 4 articles about N-benzyl-N-(trifluoromethanesulfonyl)-(phenylsulfanyl)difluoromethanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -10 - 20 ℃;
for 1.5h;
DOI:10.1021/jo800272q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: magnesium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2: sulfur dioxide; cesium fluoride / acetonitrile / -40 - 20 °C / Inert atmosphere
3: 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate / acetonitrile / -40 - 20 °C / Inert atmosphere
4: 1,2-dichloro-ethane / 20 h / 50 °C / Inert atmosphere
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
With
1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate; sulfur dioxide; magnesium; N-ethyl-N,N-diisopropylamine; cesium fluoride;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.jfluchem.2011.06.041
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfur dioxide; cesium fluoride / acetonitrile / -40 - 20 °C / Inert atmosphere
2: 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate / acetonitrile / -40 - 20 °C / Inert atmosphere
3: 1,2-dichloro-ethane / 20 h / 50 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
With
1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate; sulfur dioxide; N-ethyl-N,N-diisopropylamine; cesium fluoride;
In
dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.jfluchem.2011.06.041
