N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide

Base Information

• Chemical Name: N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide
• CAS No.: 1108658-29-2
• Molecular Formula: C₁₆H₂₃NO₅S
• Molecular Weight: 341.428
• Mol file: 1108658-29-2.mol

Synonyms:N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide

Chemical Property of N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide

There total 1 articles about N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

tert-butyl (cyclopropylsulfonyl)carbamate (681808-26-4) + benzyl bromomethyl ether (17690-16-3) → N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide (1108658-29-2)

Guidance literature:

tert-butyl (cyclopropylsulfonyl)carbamate; With n-butyllithium; In tetrahydrofuran; at -80 ℃; for 0.166667h;

benzyl bromomethyl ether; at -80 - -30 ℃;

Reference yield:

N-Boc-1-benzyloxymethyl-cyclopropanesulfonic acid amide (1108658-29-2) → tert-butyl (1-formylcyclopropyl)sulfonylcarbamate (1108658-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 50 °C

2: pyridinium chlorochromate / dichloromethane

With palladium 10% on activated carbon; hydrogen; pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/j.bmcl.2015.07.020

upstream raw materials:

tert-butyl (cyclopropylsulfonyl)carbamate

benzyl bromomethyl ether

Downstream raw materials:

tert-butyl (1-formylcyclopropyl)sulfonylcarbamate

Refernces

• 1、 -. "MACROCYCLIC SERINE PROTEASE INHIBITORS". Page/Page column 110-111. . Retrieved 2009/03/07.