N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine

Base Information

• Chemical Name: N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine
• CAS No.: 1454334-50-9
• Molecular Formula: C₂₉H₂₈F₃N₅O
• Molecular Weight: 519.569

Synonyms:N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine

Chemical Property of N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine

There total 3 articles about N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N9-[(3'-adamantan-1-yl)-4'-hydroxybenzyl]-6-aminopurine (1454334-46-3) + 1-(bromomethyl)-2,3,4-trifluorobenzene (157911-55-2) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine (1454334-50-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.2174/157018012804586996

Reference yield:

2-(adamantan-1-yl)-4-(chloromethyl)phenol (1454334-47-4) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine (1454334-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.2174/157018012804586996

Reference yield:

4-hydroxybenzyl chloride (35421-08-0) → N9-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine (1454334-50-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; acetic acid / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: |Friedel-Crafts Alkylation;

DOI:10.2174/157018012804586996

upstream raw materials:

N₉-[(3'-adamantan-1-yl)-4'-hydroxybenzyl]-6-aminopurine

1-(bromomethyl)-2,3,4-trifluorobenzene

2-(adamantan-1-yl)-4-(chloromethyl)phenol

4-hydroxybenzyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1454334-50-9 N₉-[(3'-adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)benzyl]-6-aminopurine

Send

Send

Metric Ton KG G Pound L ML

Send

Send