N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide

Base Information

• Chemical Name: N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide
• CAS No.: 1350515-59-1
• Molecular Formula: C₂₀H₁₅ClN₄O₂S
• Molecular Weight: 410.884
• Mol file: 1350515-59-1.mol

Synonyms:N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide

Chemical Property of N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide

There total 4 articles about N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

6-methoxybenzothiazol-2-ylamine (1747-60-0) + 2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid (16344-26-6) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide (1350515-59-1)

Guidance literature:

2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

6-methoxybenzothiazol-2-ylamine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2011.09.060

Reference yield:

ethyl 2-((4-chlorophenyl)amino)nicotinate (918907-41-2) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide (1350515-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 2 h / Reflux

2.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.09.060

Reference yield:

ethyl 2-chloronicotinate (1452-94-4) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[(4-chlorophenyl)amino]-3-pyridinecarboxamide (1350515-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylene glycol / 6 h / 160 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.09.060

upstream raw materials:

ethyl 2-((4-chlorophenyl)amino)nicotinate

6-methoxybenzothiazol-2-ylamine

2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid

4-chloro-aniline