Diethyl ((5-((triisopropylsilyl) oxy) pyridin-2-yl)methyl) phosphonate

Base Information

• Chemical Name: Diethyl ((5-((triisopropylsilyl) oxy) pyridin-2-yl)methyl) phosphonate
• CAS No.: 618386-06-4
• Molecular Formula: C₁₉H₃₆NO₄PSi
• Molecular Weight: 401.558
• Mol file: 618386-06-4.mol

Synonyms:(5-triisopropylsilanyloxypyridin-2-ylmethyl)phosphonic acid diethyl ester

Chemical Property of Diethyl ((5-((triisopropylsilyl) oxy) pyridin-2-yl)methyl) phosphonate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl ((5-((triisopropylsilyl) oxy) pyridin-2-yl)methyl) phosphonate

There total 3 articles about Diethyl ((5-((triisopropylsilyl) oxy) pyridin-2-yl)methyl) phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-methyl-5-triisopropylsilanyloxypyridine (1029100-88-6) + diethyl chlorophosphate (814-49-3) → (5-triisopropylsilanyloxypyridin-2-ylmethyl)phosphonic acid diethyl ester (618386-06-4)

Guidance literature:

2-methyl-5-triisopropylsilanyloxypyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

diethyl chlorophosphate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

DOI:10.1021/jm0502236

Reference yield:

5-Hydroxy-2-methylpyridine (1121-78-4) → (5-triisopropylsilanyloxypyridin-2-ylmethyl)phosphonic acid diethyl ester (618386-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / imidazole / dimethylformamide / 2 h

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 68 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm0502236

Reference yield:

triisopropylsilyl chloride (13154-24-0) → (5-triisopropylsilanyloxypyridin-2-ylmethyl)phosphonic acid diethyl ester (618386-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / imidazole / dimethylformamide / 2 h

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 68 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm0502236

upstream raw materials:

2-methyl-5-triisopropylsilanyloxypyridine

diethyl chlorophosphate

5-Hydroxy-2-methylpyridine

triisopropylsilyl chloride

Downstream raw materials:

(+)-(3R,3aS,4S,4aR,9aR)-decahydro-4-[(E)-2-[5-[3-(trifluoromethy)phenyl]l-2-pyridinyl]ethenyl]-3-methylnaphtho-[2,3-c]furan-1(3H)-one