7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

Base Information

Chemical Name:7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid
CAS No.:1202890-25-2
Molecular Formula:C₃₁H₂₆ClNO₅
Molecular Weight:528.004
Hs Code.:

Synonyms:7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

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Chemical Property of 7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

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Technology Process of 7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

There total 11 articles about 7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1202890-24-1
ethyl 7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylate

: 1202890-25-2
7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

Guidance literature:: ethyl 7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1202890-25-2
7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

2.2: 1 h / 20 °C / Industry scale

3.1: sodium hydroxide / water / Industry scale

3.2: pH 2 - 3 / Industry scale

3.3: 16 h / Reflux

4.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

6.2: 1 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 72 h / 20 °C

With hydrogenchloride; oxalyl dichloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; caesium carbonate; N,N-dimethyl-formamide; copper(l) chloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;

Reference yield:

: 1202889-56-2
3-chloro-1-(5-chloro-2,4-dihydroxyphenyl)propan-1-one

: 1202890-25-2
7-(4-(2-(biphenyl-4-yl)ethylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water / 10 - 20 °C / Industry scale

1.2: 1 h / 5 - 20 °C

2.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

2.2: 20 °C / Industry scale

3.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

3.2: 1 h / 20 °C / Industry scale

4.1: sodium hydroxide / water / Industry scale

4.2: pH 2 - 3 / Industry scale

4.3: 16 h / Reflux

5.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

7.2: 1 h / 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 72 h / 20 °C

With hydrogenchloride; oxalyl dichloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; caesium carbonate; N,N-dimethyl-formamide; copper(l) chloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;