Technology Process of 2-chloro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl α-D-mannopyranoside
There total 4 articles about 2-chloro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl α-D-mannopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 2.5h;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
2: methanol; sodium methylate / 20 °C
With
methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); sodium methylate;
In
1,4-dioxane;
1: Suzuki-Miyaura coupling;
DOI:10.1021/jm300192x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trimethylsilyl trifluoromethanesulfonate / toluene / 2 h / 20 °C / Inert atmosphere; Molecular sieve
2: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
3: methanol; sodium methylate / 20 °C
With
methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); trimethylsilyl trifluoromethanesulfonate; sodium methylate;
In
1,4-dioxane; toluene;
2: Suzuki-Miyaura coupling;
DOI:10.1021/jm300192x